Magnetic resonance histology.

The closing sentence of Paul Lauterbur’s seminal article on MRI is “Zeugmatographic (imaging) techniques should find many useful applications in studies of the internal structures, states and composition of microscopic objects”. His innovation opened a world of applications for MRI in medicine and biology. This talk will focus on the cycle of innovation and application that has propelled us to MR histology at spatial resolution more than 100,000 X that of the clinical domain. This application has in turn driven innovation to increase the resolution and extend the technique to quantitative measures of connectivity in mouse and rat models of disease and injury.